CTLA-4 blockade increases antigen-specific CD8(+) T cells in prevaccinated patients with melanoma: three cases

BACKGROUND: Anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibodies, such as ipilimumab, have generated measurable immune responses to Melan-A, NY-ESO-1, and gp100 antigens in metastatic melanoma. Vaccination against such targets has potential for immunogenicity and may produce an effector-memory...

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Detalhes bibliográficos
Main Authors: Yuan, Jianda, Ginsberg, Brian, Page, David, Li, Yanyun, Rasalan, Teresa, Gallardo, Humilidad F., Xu, Yinyan, Adams, Sylvia, Bhardwaj, Nina, Busam, Klaus, Old, Lloyd J., Allison, James P., Jungbluth, Achim, Wolchok, Jedd D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2011
Assuntos:
Focussed Research Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654853/
https://ncbi.nlm.nih.gov/pubmed/21465316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-1011-9
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