CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

Blockade of inhibitory signals mediated by cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) has been shown to enhance T cell responses and induce durable clinical responses in patients with metastatic melanoma. The functional impact of anti-CTLA-4 therapy on human immune responses is still uncle...

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Hauptverfasser: Yuan, Jianda, Gnjatic, Sacha, Li, Hao, Powel, Sarah, Gallardo, Humilidad F., Ritter, Erika, Ku, Geoffrey Y., Jungbluth, Achim A., Segal, Neil H., Rasalan, Teresa S., Manukian, Gregor, Xu, Yinyan, Roman, Ruth-Ann, Terzulli, Stephanie L., Heywood, Melanie, Pogoriler, Evelina, Ritter, Gerd, Old, Lloyd J., Allison, James P., Wolchok, Jedd D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629307/
https://ncbi.nlm.nih.gov/pubmed/19074257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810114105
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