A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system

Bispecific T-cell engagers (BiTEs) may break multiple barriers that currently limit the use of immunotherapy in glioblastoma patients. We have recently described a novel BiTE specific for a mutated form of the epidermal growth factor receptor, EGFRvIII, that exerts potent antineoplastic effects agai...

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Bibliographic Details
Main Authors: Choi, Bryan D., Pastan, Ira, Bigner, Darell D., Sampson, John H.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654588/
https://ncbi.nlm.nih.gov/pubmed/23734318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.23639
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