Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.

Vaccination with cytokine-producing tumor cells generates potent immune responses against tumors outside the central nervous system (CNS). The CNS, however, is a barrier to allograft and xenograft rejection, and established tumors within the CNS have failed to respond to other forms of systemic immu...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Sampson, J H, Archer, G E, Ashley, D M, Fuchs, H E, Hale, L P, Dranoff, G, Bigner, D D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38396/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816812/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.19.10399
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