Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.

Vaccination with cytokine-producing tumor cells generates potent immune responses against tumors outside the central nervous system (CNS). The CNS, however, is a barrier to allograft and xenograft rejection, and established tumors within the CNS have failed to respond to other forms of systemic immu...

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Bibliographic Details
Main Authors: Sampson, J H, Archer, G E, Ashley, D M, Fuchs, H E, Hale, L P, Dranoff, G, Bigner, D D
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC38396/
https://ncbi.nlm.nih.gov/pubmed/8816812
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