Low glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditions

BACKGROUND/AIMS: β-Cell apoptosis caused by increased endoplasmic reticulum (ER) stress is an important pathogenic component of type 2 diabetes mellitus. In theory, sulfonylureas, used for the treatment of diabetes, can contribute to ER stress. We assessed changes in ER stress in pancreatic β-cells...

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Detalhes bibliográficos
Main Authors: Kwon, Min Jeong, Chung, Hye Suk, Yoon, Chang Shin, Lee, Eun Ju, Kim, Tae Kyun, Lee, Soon Hee, Ko, Kyung Soo, Rhee, Byoung Doo, Kim, Mi Kyung, Park, Jeong Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Association of Internal Medicine 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654132/
https://ncbi.nlm.nih.gov/pubmed/23682228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3904/kjim.2013.28.3.339
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