Glucolipotoxicity Impairs Ceramide Flow from the Endoplasmic Reticulum to the Golgi Apparatus in INS-1 β-Cells

Accumulating evidence suggests that glucolipotoxicity, arising from the combined actions of elevated glucose and free fatty acid levels, acts as a key pathogenic component in type II diabetes, contributing to β-cell dysfunction and death. Endoplasmic reticulum (ER) stress is among the molecular path...

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Autores principales: Gjoni, Enida, Brioschi, Loredana, Cinque, Alessandra, Coant, Nicolas, Islam, M. Nurul, Ng, Carl K. -Y., Verderio, Claudia, Magnan, Christophe, Riboni, Laura, Viani, Paola, Le Stunff, Hervé, Giussani, Paola
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211692/
https://ncbi.nlm.nih.gov/pubmed/25350564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110875
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