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Inactivation of a transfected gene in human fibroblasts can occur by deletion, amplification, phenotypic switching, or methylation.

Plasmids containing the bacterial gpt gene under control of the simian virus 40 promoter were transfected into a simian virus 40-transformed human fibroblast line. Two transfectants, E2 and C10, which contain stably integrated single copies of the gpt gene, were isolated. These two lines produce Gpt...

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Detalhes bibliográficos
Main Authors: Gebara, M M, Drevon, C, Harcourt, S A, Steingrimsdottir, H, James, M R, Burke, J F, Arlett, C F, Lehmann, A R
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC365234/
https://ncbi.nlm.nih.gov/pubmed/3110595
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