TYK2-STAT1-BCL2 Pathway Dependence in T-Cell Acute Lymphoblastic Leukemia

Targeted molecular therapy has yielded remarkable outcomes in certain cancers, but specific therapeutic targets remain elusive for many others. As a result of two independent RNA interference (RNAi) screens, we identified pathway dependence on a member of the JAK tyrosine kinase family, TYK2, and it...

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Main Authors: Sanda, Takaomi, Tyner, Jeffrey W., Gutierrez, Alejandro, Ngo, Vu N., Glover, Jason, Chang, Bill H., Yost, Arla, Ma, Wenxue, Fleischman, Angela G., Zhou, Wenjun, Yang, Yandan, Kleppe, Maria, Ahn, Yebin, Tatarek, Jessica, Kelliher, Michelle A., Neuberg, Donna S., Levine, Ross L., Moriggl, Richard, Müller, Mathias, Gray, Nathanael S., Jamieson, Catriona H. M., Weng, Andrew P., Staudt, Louis M., Druker, Brian J., Look, A. Thomas
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651770/
https://ncbi.nlm.nih.gov/pubmed/23471820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0504
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