Anti-leukaemic Activity of the TYK2 selective inhibitor NDI-031301 in T-cell Acute Lymphoblastic Leukaemia

Activation of tyrosine kinase 2 (TYK2) contributes to the aberrant survival of T-cell acute lymphoblastic leukaemia (T-ALL) cells. Here we demonstrate the anti-leukaemic activity of a novel TYK2 inhibitor, NDI-031301. NDI-031301 is a potent and selective inhibitor of TYK2 that induced robust growth...

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Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Akahane, Koshi, Li, Zhaodong, Etchin, Julia, Berezovskaya, Alla, Gjini, Evisa, Masse, Craig E., Miao, Wenyan, Rocnik, Jennifer, Kapeller, Rosana, Greenwood, Jeremy R., Tiv, Hong, Sanda, Takaomi, Weinstock, David M., Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384871/
https://ncbi.nlm.nih.gov/pubmed/28295194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14563
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