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Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector.

We introduced a human beta-globin gene into murine erythroleukemia (MEL) cells by infection with recombinant retroviruses containing the complete genomic globin sequence. The beta-globin gene was correctly regulated during differentiation, steady-state mRNA levels being induced 5- to 30-fold after t...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Principais autores: Cone, R D, Weber-Benarous, A, Baorto, D, Mulligan, R C
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 1987
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365147/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3029570/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.7.2.887-897.1987
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