A Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of Its Complex with Catechol Estrogen()

Catechol estrogens are steroid metabolites that elicit physiological responses through binding to a variety of cellular targets. We show here that catechol estrogens directly inhibit soluble adenylyl cyclases and the abundant trans-membrane adenylyl cyclases. Catechol estrogen inhibition is non-comp...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Steegborn, Clemens, Litvin, Tatiana N., Hess, Kenneth C., CapperM, Austin B., Taussig, Ronald, Buck, Jochen, Levin, Lonny R., Wu, Hao
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2005
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650720/
https://ncbi.nlm.nih.gov/pubmed/16002394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M507144200
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