Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome

Local extracellular acidification has been demonstrated at sites of ischemia and inflammation. IL-1β is one of the key proinflammatory cytokines, and thus, its synthesis and secretion are tightly regulated. The NLRP3 (nucleotide-binding domain leucine-rich repeat containing family, pyrin domain cont...

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Bibliografiske detaljer
Main Authors: Rajamäki, Kristiina, Nordström, Tommy, Nurmi, Katariina, Åkerman, Karl E. O., Kovanen, Petri T., Öörni, Katariina, Eklund, Kari K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650379/
https://ncbi.nlm.nih.gov/pubmed/23530046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426254
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