Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation

Inflammasomes are intracellular protein platforms, which, upon activation, produce the highly proinflammatory cytokines interleukin (IL)-1β and IL-18. Heme, hemin and their degradation products possess significant immunomodulatory functions. Here, we studied whether hemin regulates inflammasome func...

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Bibliografiske detaljer
Udgivet i:J Innate Immun
Main Authors: Nurmi, Katariina, Kareinen, Ilona, Virkanen, Juhani, Rajamäki, Kristiina, Kouri, Vesa-Petteri, Vaali, Kirsi, Levonen, Anna-Liisa, Fyhrquist, Nanna, Matikainen, Sampsa, Kovanen, Petri T., Eklund, Kari K.
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738905/
https://ncbi.nlm.nih.gov/pubmed/27655219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000448894
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