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Tumor necrosis factor primes and metal particles activate the NLRP3 inflammasome in human primary macrophages
Aseptic loosening of total joint replacements is driven by a macrophage-mediated inflammatory reaction to implant-derived wear particles. Phagocytosis of implant debris has been suggested to activate the NLRP3 inflammasome leading to secretion of interleukin (IL)-1 β. However, factors and molecular...
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| Publicado no: | Acta Biomater |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7729209/ https://ncbi.nlm.nih.gov/pubmed/32194260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2020.03.017 |
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