Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts

MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to derepression of let-7 targets at levels that exceed 10-fold to 100-fold wit...

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Detalhes bibliográficos
Main Authors: Gurtan, Allan M., Ravi, Arvind, Rahl, Peter B., Bosson, Andrew D., JnBaptiste, Courtney K., Bhutkar, Arjun, Whittaker, Charles A., Young, Richard A., Sharp, Phillip A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650230/
https://ncbi.nlm.nih.gov/pubmed/23630078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.215376.113
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