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In vivo structure–function analysis of human Dicer reveals directional processing of precursor miRNAs
Dicer is an RNase III family endoribonuclease and haploinsufficient tumor suppressor that processes mature miRNAs from the 5′ (5p) or 3′ (3p) arm of hairpin precursors. In murine Dicer knockout fibroblasts, we expressed human Dicer with point mutations in the RNase III, helicase, and PAZ domains and...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358635/ https://ncbi.nlm.nih.gov/pubmed/22546613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.032680.112 |
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