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Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1–3 family

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression critical for organismal viability. Changes in miRNA activity are common in cancer, but how these changes relate to subsequent alterations in transcription and the process of tumorigenesis is not well understood. Here, we repor...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: JnBaptiste, Courtney K., Gurtan, Allan M., Thai, Kevin K., Lu, Victoria, Bhutkar, Arjun, Su, Mei-Ju, Rotem, Asaf, Jacks, Tyler, Sharp, Phillip A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411708/
https://ncbi.nlm.nih.gov/pubmed/28446596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.296301.117
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