LAB/NTAL Facilitates Fungal/PAMP-induced IL-12 and IFN-γ Production by Repressing β-Catenin Activation in Dendritic Cells

Fungal pathogens elicit cytokine responses downstream of immunoreceptor tyrosine-based activation motif (ITAM)-coupled or hemiITAM-containing receptors and TLRs. The Linker for Activation of B cells/Non-T cell Activating Linker (LAB/NTAL) encoded by Lat2, is a known regulator of ITAM-coupled recepto...

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Detalhes bibliográficos
Main Authors: Orr, Selinda J., Burg, Ashley R., Chan, Tim, Quigley, Laura, Jones, Gareth W., Ford, Jill W., Hodge, Deborah, Razzook, Catherine, Sarhan, Joseph, Jones, Yava L., Whittaker, Gillian C., Boelte, Kimberly C., Lyakh, Lyudmila, Cardone, Marco, O'Connor, Geraldine M., Tan, Cuiyan, Li, Hongchuan, Anderson, Stephen K., Jones, Simon A., Zhang, Weiguo, Taylor, Philip R., Trinchieri, Giorgio, McVicar, Daniel W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649983/
https://ncbi.nlm.nih.gov/pubmed/23675302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003357
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