The Linker for Activation of B Cells (LAB)/Non-T Cell Activation Linker (NTAL) Regulates Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Signaling and Macrophage Inflammatory Responses Independently of the Linker for Activation of T Cells

Triggering receptor expressed on myeloid cells-2 (TREM-2) is rapidly emerging as a key regulator of the innate immune response via its regulation of macrophage inflammatory responses. Here we demonstrate that proximal TREM-2 signaling parallels other DAP12-based receptor systems in its use of Syk an...

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Autores principales: Whittaker, Gillian C., Orr, Selinda J., Quigley, Laura, Hughes, Laurel, Francischetti, Ivo M. B., Zhang, Weigou, McVicar, Daniel W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823438/
https://ncbi.nlm.nih.gov/pubmed/19948717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038398
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