LAB/NTAL Facilitates Fungal/PAMP-induced IL-12 and IFN-γ Production by Repressing β-Catenin Activation in Dendritic Cells

Fungal pathogens elicit cytokine responses downstream of immunoreceptor tyrosine-based activation motif (ITAM)-coupled or hemiITAM-containing receptors and TLRs. The Linker for Activation of B cells/Non-T cell Activating Linker (LAB/NTAL) encoded by Lat2, is a known regulator of ITAM-coupled recepto...

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Détails bibliographiques
Auteurs principaux: Orr, Selinda J., Burg, Ashley R., Chan, Tim, Quigley, Laura, Jones, Gareth W., Ford, Jill W., Hodge, Deborah, Razzook, Catherine, Sarhan, Joseph, Jones, Yava L., Whittaker, Gillian C., Boelte, Kimberly C., Lyakh, Lyudmila, Cardone, Marco, O'Connor, Geraldine M., Tan, Cuiyan, Li, Hongchuan, Anderson, Stephen K., Jones, Simon A., Zhang, Weiguo, Taylor, Philip R., Trinchieri, Giorgio, McVicar, Daniel W.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649983/
https://ncbi.nlm.nih.gov/pubmed/23675302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003357
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