Contribution of V(H) replacement products to the generation of anti-HIV antibodies

V(H) replacement occurs through RAG-mediated secondary recombination to change unwanted IgH genes and diversify antibody repertoire. The biological significance of V(H) replacement remains to be explored. Here, we show that V(H) replacement products are highly enriched in IgH genes encoding anti-HIV...

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Bibliographic Details
Main Authors: Liao, Hongyan, Guo, Jun-tao, Lange, Miles D., Fan, Run, Zemlin, Michael, Su, Kaihong, Guan, Yongjun, Zhang, Zhixin
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649862/
https://ncbi.nlm.nih.gov/pubmed/23220404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2012.11.003
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