Contribution of V(H) replacement products to the generation of anti-HIV antibodies

V(H) replacement occurs through RAG-mediated secondary recombination to change unwanted IgH genes and diversify antibody repertoire. The biological significance of V(H) replacement remains to be explored. Here, we show that V(H) replacement products are highly enriched in IgH genes encoding anti-HIV...

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Autori principali: Liao, Hongyan, Guo, Jun-tao, Lange, Miles D., Fan, Run, Zemlin, Michael, Su, Kaihong, Guan, Yongjun, Zhang, Zhixin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649862/
https://ncbi.nlm.nih.gov/pubmed/23220404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2012.11.003
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