Conformation-Dependent Recognition of HIV gp120 by Designed Ankyrin Repeat Proteins Provides Access to Novel HIV Entry Inhibitors

Here, we applied the designed ankyrin repeat protein (DARPin) technology to develop novel gp120-directed binding molecules with HIV entry-inhibiting capacity. DARPins are interesting molecules for HIV envelope inhibitor design, as their high-affinity binding differs from that of antibodies. DARPins...

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Detalhes bibliográficos
Main Authors: Mann, Axel, Friedrich, Nikolas, Krarup, Anders, Weber, Jacqueline, Stiegeler, Emanuel, Dreier, Birgit, Pugach, Pavel, Robbiani, Melissa, Riedel, Tina, Moehle, Kerstin, Robinson, John A., Rusert, Peter, Plückthun, Andreas, Trkola, Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648163/
https://ncbi.nlm.nih.gov/pubmed/23487463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00152-13
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