Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact To Facilitate the DNA Damage Response

FANCJ mutations are linked to Fanconi anemia (FA) and increase breast cancer risk. FANCJ encodes a DNA helicase implicated in homologous recombination (HR) repair of double-strand breaks (DSBs) and interstrand cross-links (ICLs), but its mechanism of action is not well understood. Here we show with...

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Hauptverfasser: Suhasini, Avvaru N., Sommers, Joshua A., Muniandy, Parameswary A., Coulombe, Yan, Cantor, Sharon B., Masson, Jean-Yves, Seidman, Michael M., Brosh, Robert M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648079/
https://ncbi.nlm.nih.gov/pubmed/23530059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01256-12
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