Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes

Fanconi anemia (FA) is a genetic disease characterized by congenital abnormalities, bone marrow failure, and susceptibility to leukemia and other cancers. FANCJ, one of 13 genes linked to FA, encodes a DNA helicase proposed to operate in homologous recombination repair and replicational stress respo...

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Detalhes bibliográficos
Main Authors: Wu, Yuliang, Sommers, Joshua A., Suhasini, Avvaru N., Leonard, Thomas, Deakyne, Julianna S., Mazin, Alexander V., Shin-ya, Kazuo, Kitao, Hiroyuki, Brosh, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981534/
https://ncbi.nlm.nih.gov/pubmed/20639400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-256016
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