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Impaired Gating of an L-Type Ca(2+) Channel Carrying a Mutation Linked to Malignant Hyperthermia

Recently, we characterized the functional properties of a mutant skeletal muscle L-type Ca(2+) channel (Ca(V)1.1 R174W) linked to the pharmacogenetic disorder malignant hyperthermia. Although the R174W mutation neutralizes the innermost basic amino acid in the voltage-sensing S4 helix of the first c...

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Autors principals: Bannister, Roger A., Beam, Kurt G.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647151/
https://ncbi.nlm.nih.gov/pubmed/23663834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.03.035
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