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Impaired Gating of an L-Type Ca(2+) Channel Carrying a Mutation Linked to Malignant Hyperthermia
Recently, we characterized the functional properties of a mutant skeletal muscle L-type Ca(2+) channel (Ca(V)1.1 R174W) linked to the pharmacogenetic disorder malignant hyperthermia. Although the R174W mutation neutralizes the innermost basic amino acid in the voltage-sensing S4 helix of the first c...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3647151/ https://ncbi.nlm.nih.gov/pubmed/23663834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.03.035 |
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