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Physiology of the intrathecal bolus: the leptomeningeal route for macromolecule and particle delivery to CNS
Presently, there are no effective treatments for several diseases involving the CNS, which is protected by the blood-brain, blood-CSF and blood-arachnoid barriers. Traversing any of these barriers is difficult, especially for macromolecular drugs and particulates. However, there is significant exper...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3646927/ https://ncbi.nlm.nih.gov/pubmed/23316936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300474m |
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