Large-Volume Intrathecal Administrations: Impact on CSF Pressure and Safety Implications

The increasing number of studies demonstrates the high potency of the intrathecal (IT) route for the delivery of biopharmaceuticals to the central nervous system (CNS). Our earlier data exhibited that both the infused volume and the infusion rate can regulate the initial disposition of the administe...

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Bibliografiska uppgifter
I publikationen:Front Neurosci
Huvudupphovsmän: Belov, Vasily, Appleton, Janine, Levin, Stepan, Giffenig, Pilar, Durcanova, Beata, Papisov, Mikhail
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2021
Ämnen:
Neuroscience
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079755/
https://ncbi.nlm.nih.gov/pubmed/33935624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.604197
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