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Large-Volume Intrathecal Administrations: Impact on CSF Pressure and Safety Implications

The increasing number of studies demonstrates the high potency of the intrathecal (IT) route for the delivery of biopharmaceuticals to the central nervous system (CNS). Our earlier data exhibited that both the infused volume and the infusion rate can regulate the initial disposition of the administe...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Belov, Vasily, Appleton, Janine, Levin, Stepan, Giffenig, Pilar, Durcanova, Beata, Papisov, Mikhail
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079755/
https://ncbi.nlm.nih.gov/pubmed/33935624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.604197
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