The Configuration of the Perivascular System Transporting Macromolecules in the CNS

Large blood vessels entering the CNS are surrounded by perivascular spaces that communicate with the cerebrospinal fluid and, at their termini, with the interstitial space. Solutes and particles can translocate along these perivascular conduits, reportedly in both directions. Recently, this prompted...

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Autores principales: Beata Durcanova, Janine Appleton, Nyshidha Gurijala, Vasily Belov, Pilar Giffenig, Elisabeth Moeller, Matthew Hogan, Fredella Lee, Mikhail Papisov
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019-05-01
Colección:Frontiers in Neuroscience
Materias:
perivascular space
Virchow–Robin space
cerebrospinal fluid
intrathecal
drug delivery
biopharmaceuticals
Acceso en línea:https://www.frontiersin.org/article/10.3389/fnins.2019.00511/full
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