A prognostic signature of G₂ checkpoint function in melanoma cell lines

As DNA damage checkpoints are barriers to carcinogenesis, G(2) checkpoint function was quantified to test for override of this checkpoint during melanomagenesis. Primary melanocytes displayed an effective G(2) checkpoint response to ionizing radiation (IR)-induced DNA damage. Thirty-seven percent of...

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Bibliographic Details
Main Authors: Omolo, Bernard, Carson, Craig, Chu, Haitao, Zhou, Yingchun, Simpson, Dennis A., Hesse, Jill E., Paules, Richard S., Nyhan, Kristine C., Ibrahim, Joseph G., Kaufmann, William K.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646863/
https://ncbi.nlm.nih.gov/pubmed/23454897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24067
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