Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice

ATP-binding cassette transporter A1 (ABCA1) transporter regulates cholesterol efflux and is an essential mediator of high-density lipoprotein (HDL) formation. In amyloid precursor protein (APP) transgenic mice, Abca1 deficiency increased amyloid deposition in the brain paralleled by decreased levels...

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Autores principales: Fitz, Nicholas F., Cronican, Andrea A., Saleem, Muzamil, Fauq, Abdul H., Chapman, Robert, Lefterov, Iliya, Koldamova, Radosveta
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2012
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646580/
https://ncbi.nlm.nih.gov/pubmed/22993429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1937-12.2012
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