A microRNA miR-34a Regulated Bimodal Switch targets Notch in Colon Cancer Stem Cells

microRNAs regulate developmental cell fate decisions, tissue homeostasis and oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor microRNA miR-34a is a cell fate determinant in early stage dividing colon cancer stem cells (CCSCs). In pair-cell assays, miR34a dis...

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書誌詳細
主要な著者: Bu, Pengcheng, Chen, Kai-Yuan, Chen, Joyce Huan, Wang, Lihua, Walters, Jewell, Shin, Yong Jun, Goerger, Julian P., Sun, Jian, Witherspoon, Mavee, Rakhilin, Nikolai, Li, Jiahe, Yang, Herman, Milsom, Jeff, Lee, Sang, Zipfel, Warren, Jin, Moonsoo M., Gümüşcedil, Zeynep H., Lipkin, Steven M., Shen, Xiling
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646336/
https://ncbi.nlm.nih.gov/pubmed/23642368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.03.002
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