14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′-rich switch regions for class switch recombination

Class switch DNA recombination (CSR) is the mechanism that diversifies the biological effector functions of antibodies. Activation-induced cytidine deaminase (AID), a key CSR player, targets IgH switch (S) regions, which contain 5′-AGCT-3′ repeats in their core. How AID is recruited to S regions rem...

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Main Authors: Xu, Zhenming, Fulop, Zsolt, Wu, Guikai, Pone, Egest J., Zhang, Jinsong, Mai, Thach, Thomas, Lisa M., Al-Qahtani, Ahmed, White, Clayton A., Park, Seok-Rae, Steinacker, Petra, Li, Zenggang, Yates, John, Herron, Bruce, Otto, Markus, Zan, Hong, Fu, Haian, Casali, Paolo
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645988/
https://ncbi.nlm.nih.gov/pubmed/20729863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1884
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