Folylpoly-Glutamate Synthetase Expression is associated with Tumor Response and Outcome from Pemetrexed-based Chemotherapy in Malignant Pleural Mesothelioma

PURPOSE: Pemetrexed-based chemotherapy represents the standard of care in firstline-treatment of advanced malignant pleural mesothelioma (MPM). However, there are no established predictors of clinical benefit. Pemetrexed inhibits multiple enzymes involved in pyrimidine and purine synthesis, but the...

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Autori principali: Christoph, Daniel C., Asuncion, Bernadette Reyna, Mascaux, Celine, Tran, Cindy, Lu, Xian, Wynes, Murry W., Gauler, Thomas C., Wohlschlaeger, Jeremias, Theegarten, Dirk, Neumann, Volker, Hepp, Rodrigo, Welter, Stefan, Stamatis, Georgios, Tannapfel, Andrea, Schuler, Martin, Eberhardt, Wilfried E., Hirsch, Fred R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645940/
https://ncbi.nlm.nih.gov/pubmed/22895141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e318260deaa
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