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Concentration-Dependent Processivity of Multiple Glutamate Ligations Catalyzed by Folylpoly-γ-glutamate Synthetase

Folylpoly-γ-glutamate synthetase (FPGS, EC 6.3.2.17) is an ATP-dependent ligase that catalyzes formation of poly-γ-glutamate derivatives of reduced folates and anti-folates such as methotrexate and 5,10-dideaza-5,6,7,8-tetrahydrofolate (DDAH(4)PteGlu(1)). While the chemical mechanism of the reaction...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Tomsho, John W., Moran, Richard G., Coward, James K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805413/
https://ncbi.nlm.nih.gov/pubmed/18672898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800406w
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