Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis

Progression of solid tumors to the metastatic stage is accountable for the majority of cancer-related deaths. Further understanding of the molecular mechanisms governing metastasis is essential for the development of antimetastatic regimens. Here, we aimed to identify Rac activators that could promo...

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Main Authors: Laurin, Mélanie, Huber, Jennifer, Pelletier, Ariane, Houalla, Tarek, Park, Morag, Fukui, Yoshinori, Haibe-Kains, Benjamin, Muller, William J., Côté, Jean-François
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645577/
https://ncbi.nlm.nih.gov/pubmed/23592719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213050110
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