High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase

Glycerophosphocholine (GPC) is high in cells of the renal inner medulla where high interstitial NaCl and urea power concentration of the urine. GPC protects inner medullary cells against the perturbing effects of high NaCl and urea by stabilizing intracellular macromolecules. Degradation of GPC is c...

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Detalhes bibliográficos
Main Authors: Topanurak, Supachai, Ferraris, Joan D., Li, Jinxi, Izumi, Yuichiro, Williams, Chester K., Gucek, Marjan, Wang, Guanghui, Zhou, Xiaoming, Burg, Maurice B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645535/
https://ncbi.nlm.nih.gov/pubmed/23589856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305220110
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