Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration

Accumulation of β-amyloid (Aβ) in the brain is a key event in Alzheimer disease pathogenesis. Apolipoprotein (Apo) E is a lipid carrier protein secreted by astrocytes, which shows inherent affinity for Aβ and has been implicated in the receptor-mediated Aβ uptake by neurons. To characterize ApoE inv...

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Bibliographische Detailangaben
Hauptverfasser: Kuszczyk, Magdalena A., Sanchez, Sandrine, Pankiewicz, Joanna, Kim, Jungsu, Duszczyk, Malgorzata, Guridi, Maitea, Asuni, Ayodeji A., Sullivan, Patrick M., Holtzman, David M., Sadowski, Martin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2013
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644726/
https://ncbi.nlm.nih.gov/pubmed/23499462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.01.034
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