In vivo hippocampal microdialysis reveals impairment of NMDA receptor–cGMP signaling in APP(SW) and APP(SW)/PS1(L166P) Alzheimer's transgenic mice

Transgenic (Tg) mice overexpressing human amyloid precursor protein (APP) mutants reproduce features of early Alzheimer's disease (AD) including memory deficit, presence of ß-amyloid (Aß) oligomers, and age-associated formation of amyloid deposits. In this study we used hippocampal microdialysi...

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Hlavní autoři: Duszczyk, Malgorzata, Kuszczyk, Magdalena, Guridi, Maitea, Lazarewicz, Jerzy W., Sadowski, Martin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508170/
https://ncbi.nlm.nih.gov/pubmed/22841892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2012.07.017
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