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Modulation of APP Expression Reduces Aβ Deposition in a Mouse Model
OBJECTIVE: Proteolytic cleavage of the amyloid precursor protein (APP) generates β-amyloid (Aβ) peptides. Prolonged accumulation of Aβ in the brain underlies the pathogenesis of Alzheimer’s disease (AD) and is regarded as a principal target for development of disease-modifying therapeutics. METHODS:...
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| Publicat a: | Ann Neurol |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4247163/ https://ncbi.nlm.nih.gov/pubmed/24687915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24149 |
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