Direct Synthesis of Fluorinated Heteroarylether Bioisosteres

[Image: see text] This work delineates a method for the modular synthesis of reagents that are capable of direct incorporation of difluoroalkyl groups onto heterocycles. The scope and generality of this method is exemplified with the difluoroethyl group (along with the introduction of a new reagent...

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Bibliografiske detaljer
Main Authors: Zhou, Qianghui, Ruffoni, Alessandro, Gianatassio, Ryan, Fujiwara, Yuta, Sella, Eran, Shabat, Doron, Baran, Phil S.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643141/
https://ncbi.nlm.nih.gov/pubmed/23460402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201300763
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