The conformational flexibility of the carboxy terminal residues 105–114 is a key modulator of the catalytic activity and stability of Macrophage Migration Inhibitory Factor (MIF)()

Macrophage migration inhibitory factor (MIF) is a multifunctional protein and a major mediator of innate immunity. Although X-ray crystallography revealed that MIF exists as a homotrimer, its oligomerization state in vivo as well as the factors governing its oligomerization and stability remain poor...

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Autori principali: El-Turk, Farah, Cascella, Michele, Ouertatani-Sakouhi, Hajer, Narayanan, Raghavendran Lakshmi, Leng, Lin, Bucala, Richard, Hweckstetter, Markus, Rothlisberger, Ursula, Lashuel, Hilal A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642871/
https://ncbi.nlm.nih.gov/pubmed/18795803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800603x
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