Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acts as a Novel Potentiator of Cyclin-dependent Kinases to Enhance Cell Proliferation Independently of Its Hydrolase Activity

Dysregulation of cell proliferation and the cell cycle are associated with various diseases, such as cancer. Cyclin-dependent kinases (CDKs) play central roles in cell proliferation and the cell cycle. Ubiquitin C-terminal hydrolase L1 (UCH-L1) is expressed in a restricted range of tissues, includin...

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Bibliographic Details
Main Authors: Kabuta, Tomohiro, Mitsui, Takeshi, Takahashi, Masaki, Fujiwara, Yuuki, Kabuta, Chihana, Konya, Chiho, Tsuchiya, Yukihiro, Hatanaka, Yusuke, Uchida, Kenko, Hohjoh, Hirohiko, Wada, Keiji
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642309/
https://ncbi.nlm.nih.gov/pubmed/23543736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.435701
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