Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

New broad and potent neutralizing HIV-1 antibodies have recently been described that are largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 family of antibodies, isolated from an African donor, neutralize ∼70% of circulating isolates with a median IC(50) less than...

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Main Authors: Julien, Jean-Philippe, Sok, Devin, Khayat, Reza, Lee, Jeong Hyun, Doores, Katie J., Walker, Laura M., Ramos, Alejandra, Diwanji, Devan C., Pejchal, Robert, Cupo, Albert, Katpally, Umesh, Depetris, Rafael S., Stanfield, Robyn L., McBride, Ryan, Marozsan, Andre J., Paulson, James C., Sanders, Rogier W., Moore, John P., Burton, Dennis R., Poignard, Pascal, Ward, Andrew B., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642082/
https://ncbi.nlm.nih.gov/pubmed/23658524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003342
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