Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours

BACKGROUND: The RNase III enzyme DICER1 plays a central role in maturation of microRNAs. Identification of neoplasia-associated germ-line and somatic mutations in DICER1 indicates that mis-expression of miRNAs in cancer may result from defects in their processing. As part of a recent study of DICER1...

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Bibliographic Details
Main Authors: Sabbaghian, Nelly, Bahubeshi, Amin, Shuen, Andrew Y, Kanetsky, Peter A, Tischkowitz, Marc D, Nathanson, Katherine L, Foulkes, William D
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Short Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642033/
https://ncbi.nlm.nih.gov/pubmed/23547758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-6-127
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