Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides

DICER1 is an endoribonuclease responsible for the production of mature microRNAs which are small, single-stranded RNA molecules that regulate gene expression post-transcriptionally by binding to mRNA and repressing the expression of target genes. Germ-line mutations in DICER1 are responsible for a r...

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Bibliographic Details
Main Authors: Sabbaghian, Nelly, Srivastava, Archana, Hamel, Nancy, Plourde, François, Gajtko-Metera, Malgorzata, Niedziela, Marek, Foulkes, William D
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
Subjects:
Short Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953921/
https://ncbi.nlm.nih.gov/pubmed/24065110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2013.215
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