Deletion of IgG-switched Autoreactive B Cells and Defects in Fas(lpr) Lupus Mice

During a T cell-dependent antibody (Ab) response, B cells undergo Ab class-switching and variable region hypermutation, with the latter process potentially rendering previously innocuous B cells autoreactive. Class switching and hypermutation are temporally and anatomically linked with both processe...

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Autors principals: Aït-Azzouzene, Djemel, Kono, Dwight H., Gonzalez-Quintial, Rosana, McHeyzer-Williams, Louise J., Lim, Min, Wickramarachchi, Dilki, Gerdes, Tobias, Gavin, Amanda L., Skog, Patrick, McHeyzer-Williams, Michael G., Nemazee, David, Theofilopoulos, Argyrios N.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641794/
https://ncbi.nlm.nih.gov/pubmed/20554953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000698
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