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Deletion of IgG-switched Autoreactive B Cells and Defects in Fas(lpr) Lupus Mice
During a T cell-dependent antibody (Ab) response, B cells undergo Ab class-switching and variable region hypermutation, with the latter process potentially rendering previously innocuous B cells autoreactive. Class switching and hypermutation are temporally and anatomically linked with both processe...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3641794/ https://ncbi.nlm.nih.gov/pubmed/20554953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000698 |
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