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Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

Heparin is required for the binding of basic fibroblast growth factor (bFGF) to high-affinity receptors on cells deficient in cell surface heparan sulfate proteoglycan. So that this heparin requirement could be evaluated in the absence of other cell surface molecules, we designed a simple assay base...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Main Authors: Ornitz, D M, Yayon, A, Flanagan, J G, Svahn, C M, Levi, E, Leder, P
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 1992
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364088/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1309590/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.1.240
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